ZRSR2

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.^[5][6][7][8]

ZRSR2
Identifiers
Aliases	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
External IDs	OMIM: 300028; MGI: 103287; HomoloGene: 21061; GeneCards: ZRSR2; OMA:ZRSR2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 15,790,156 bp[1] End 15,830,694 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F5|X 75.99 cM Start 162,718,439 bp[2] End 162,741,657 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte monocyte tendon of biceps brachii external globus pallidus tibial arteries spleen gastric mucosa Descending thoracic aorta lymph node Top expressed in genital tubercle tail of embryo yolk sac retinal pigment epithelium zygote primitive streak embryo Epithelium of choroid plexus granulocyte muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding nucleic acid binding pre-mRNA 3'-splice site binding RNA binding protein binding Cellular component nucleus spliceosomal complex U12-type spliceosomal complex nucleoplasm U2AF complex Biological process mRNA processing spliceosomal complex assembly RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8233 22184 Ensembl ENSG00000169249 ENSMUSG00000031370 UniProt Q15696 Q62377 RefSeq (mRNA) NM_005089 NM_009453 NM_178794 RefSeq (protein) NP_005080 n/a Location (UCSC) Chr X: 15.79 – 15.83 Mb Chr X: 162.72 – 162.74 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.^[8]