ZWINT

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.^[5]

ZWINT
Identifiers
Aliases	ZWINT, HZwint-1, KNTC2AP, ZWINT1, SIP30, ZW10 interacting kinetochore protein
External IDs	OMIM: 609177; MGI: 1289227; HomoloGene: 48496; GeneCards: ZWINT; OMA:ZWINT - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.1 Start 56,357,227 bp[1] End 56,361,273 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B5.3|10 37.15 cM Start 72,490,677 bp[2] End 72,510,796 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone embryo ganglionic eminence trabecular bone bone marrow gonad rectum gingival epithelium Top expressed in ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus medial vestibular nucleus entorhinal cortex superior colliculus perirhinal cortex mammillary body inferior colliculi arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein N-terminus binding Cellular component cytoplasm neuron projection dendrite chromosome, centromeric region intracellular membrane-bounded organelle kinetochore chromosome nucleus nucleoplasm cytosol nuclear body Biological process mitotic sister chromatid segregation mitotic cell cycle checkpoint signaling cell division cell cycle establishment of localization in cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11130 52696 Ensembl ENSG00000122952 ENSMUSG00000019923 UniProt O95229 Q9CQU5 RefSeq (mRNA) NM_001005413 NM_001005414 NM_007057 NM_032997 NM_001293683 NM_001293684 NM_025635 RefSeq (protein) NP_001005413 NP_008988 NP_127490 NP_001280612 NP_001280613 NP_079911 Location (UCSC) Chr 10: 56.36 – 56.36 Mb Chr 10: 72.49 – 72.51 Mb PubMed search [3] [4]
Wikidata
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Function

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

ZWINT has been shown to interact with MIS12.^[6][7] ZWINT has also been shown to interact with RAB3C^[8]