Zn2+-exporting ATPase

In enzymology, a Zn²⁺-exporting ATPase (EC 3.6.3.5) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + Zn²⁺_in ${\displaystyle \rightleftharpoons }$ ADP + phosphate + Zn²⁺_out

zinc-exporting ATPase
Identifiers
EC no.	3.6.3.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, H₂O, and Zn²⁺, whereas its 3 products are ADP, phosphate, and Zn²⁺.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (Zn²⁺-exporting). Other names in common use include Zn(II)-translocating P-type ATPase, P1B-type ATPase, and AtHMA4 (the A. thaliana protein).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1MWY and 1MWZ. Moreover, nanobodies have recently been raised against a zinc-transporting ATPase (ZntA) which are able to bind and inhibit the ATPase activity, showing potential for further structural studies.^[1]