Receptor D1 de dopamina

DRD1
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	1OZ5
Identificadores
Nomes alternativos	DRD1
IDs externos	OMIM: 126449 HomoloGene: 30992 GeneCards: DRD1
Targeted by Drug
	A-68930, apomorfina, cabergolina, dopamina, fenoldopam, pergolide, Rotigotina, serotonina, bromocriptina, lisurida, SKF-38393, (+)-butaclamol, clorpromazina, clozapina, ecopipam, Flupentixol, flufenazina, haloperidol, cetanserina, mesoridazine, Proclorperazina, SCH-23390, espiperona, thioridazine, tavapadon, pimozida, fenoldopam, pergolide mesylate
Ontologia genética
Função molecular	• dopamine neurotransmitter receptor activity; • dopamine binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • dopamine neurotransmitter receptor activity, coupled via Gs; • G protein-coupled receptor activity; • signal transducer activity; • G-protein alpha-subunit binding;
Componente celular	• membrane; • núcleo celular; • retículo endoplasmático; • integral component of membrane; • membrana plasmática; • endoplasmic reticulum membrane; • integral component of plasma membrane; • ciliary membrane; • sistema endomembranoso; • non-motile cilium; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane; • Espinha dendrítica; • dendrito; • cell projection; • cílio;
Processo biológico	• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • contracção muscular; • protein import into nucleus; • positive regulation of potassium ion transport; • response to amphetamine; • aprendizagem; • feeding behavior; • Depressão de longa duração; • temperature homeostasis; • striatum development; • prepulse inhibition; • response to cocaine; • grooming behavior; • behavioral response to cocaine; • locomotory behavior; • dentate gyrus development; • transmission of nerve impulse; • memória; • positive regulation of synaptic transmission, glutamatergic; • Sinaptogênese; • habituação; • adult walking behavior; • movimento peristáltico; • cellular response to catecholamine stimulus; • adenylate cyclase-activating dopamine receptor signaling pathway; • regulation of dopamine uptake involved in synaptic transmission; • associative learning; • astrocyte development; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • positive regulation of release of sequestered calcium ion into cytosol; • mating behavior; • behavioral fear response; • activation of adenylate cyclase activity; • dopamine receptor signaling pathway; • Aversão ao sabor condicionada; • cerebral cortex GABAergic interneuron migration; • glucose import; • visual learning; • sensitization; • positive regulation of cell migration; • condicionamento operante; • vasodilatação; • regulation of dopamine metabolic process; • dopamine metabolic process; • phospholipase C-activating dopamine receptor signaling pathway; • Maternal behavior; • dopamine transport; • hippocampus development; • neuronal action potential; • Potenciação de longa duração; • GO:0072468 transdução de sinal; • synaptic transmission, dopaminergic; • GO:1901313 positive regulation of gene expression; • cellular response to dopamine; • regulation of protein phosphorylation; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	1812
	n/a
	ENSG00000184845
	n/a
	P21728
	n/a
	NM_000794
	n/a
	NP_000785
	n/a
	Wikidata
Ver/Editar Humano

O receptor de dopamina D₁, também conhecido como D1R, é uma proteína que, em seres humanos é codificada pelo gene DRD1. Funciona como um receptor acoplado à proteína G.^[3]

Factos rápidos DRD1, Estruturas disponíveis ...

[3]

[1]

[2]

Receptor D1 de dopamina

Referências

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