5-HT2B受体

5-羟色胺受体2B或血清素受体2B (英语:5-Hydroxytryptamine receptor 2B (5-HT_2B)或serotonin receptor 2B) 是在人类中由HTR2B基因编码的蛋白质^[6][7]。 5-HT_2B是5-HT2受体家族中的成员。

5-HT2B受体
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4NC3、​4IB4
识别号
别名	HTR2B；, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
外部ID	OMIM：601122 MGI：109323 HomoloGene：55492 GeneCards：HTR2B
为以下药物的标靶
LSD、​5-carboxamidotryptamine、​血清素、​8-OH-DPAT、​AL-37350A、​α-methyl-5-HT、​布苯丙胺、​BW-723C86、​过乳降、​CGS-12066A、​2,5-二甲氧基-4-碘代苯丙胺、​洛卡色林、​MK-212、​norfenfluramine、​Org 12962、​ORG-37684、​培高利特、​吲哚洛尔、​quinpirole、​喹哌嗪、​ru-24969、​N-(3-三氟甲基苯基)哌嗪、​色胺、​VER-3323、​brl-15572、​迈克宁（又译麦角胺）、​gr-127935、​间氯苯基哌嗪、​甲基麦角新碱、​美西麦角、​sb-216641、​1-naphthylpiperazine、​阿戈美拉汀、​阿朴吗啡、​溴隐亭、​氯氮平、​氟西汀、​glemanserin、​氟哌啶醇、​酮色林、​L-741,626、​麦角乙脲、​褪黑素、​mesulergine、​甲麦角林、​metitepine、​米塞林、​seproxetine、​哌波色罗、​吡贝地尔、​萝芙木、​ritanserin、​roxindole、​RS-102221、​RS-127445、​sarpogrelate、​SB 204741、​sb-206553、​SB 242084、​SB 243213、​SB-277,011-A、​SDZ SER-082、​spiperone、​spiramide、​spiroxatrine、​特麦角脲、​曲唑酮、​volinanserin、​呫诺美林、​育亨宾、​齐美定[1]
基因位置（人类） 染色体 2号染色体[2] 基因座 2q37.1 起始 231,108,230 bp[2] 终止 231,125,042 bp[2]
基因位置（小鼠） 染色体 小鼠1号染色体[3] 基因座 1|1 C5 起始 86,026,748 bp[3] 终止 86,039,692 bp[3]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • G protein-coupled receptor activity • GTPase activator activity • signal transducer activity • G protein-coupled serotonin receptor activity • G-protein alpha-subunit binding • serotonin binding • neurotransmitter receptor activity 细胞组分 • 细胞质 • integral component of membrane • 膜 • 细胞膜 • 突触 • 细胞连接 • neuron projection • integral component of plasma membrane • 核质 • 树突 生物学过程 • intestine smooth muscle contraction • 平滑肌收缩 • G protein-coupled receptor internalization • release of sequestered calcium ion into cytosol • regulation of behavior • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • 磷酸化 • positive regulation of cytokine production • 血管收缩 • ERK1 and ERK2 cascade • positive regulation of phosphatidylinositol biosynthetic process • cardiac muscle hypertrophy • heart morphogenesis • cellular calcium ion homeostasis • neural crest cell differentiation • negative regulation of apoptotic process • negative regulation of cell death • activation of phospholipase C activity • protein kinase C signaling • cGMP biosynthetic process • cellular response to temperature stimulus • positive regulation of GTPase activity • 心脏发育 • positive regulation of nitric-oxide synthase activity • protein kinase C-activating G protein-coupled receptor signaling pathway • embryonic morphogenesis • serotonin receptor signaling pathway • neural crest cell migration • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • phosphatidylinositol 3-kinase signaling • negative regulation of autophagy • positive regulation of cell division • calcium-mediated signaling • 信号转导 • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • G protein-coupled receptor signaling pathway • 动物行为 • cGMP-mediated signaling • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • 化学性突触传递 Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3357	15559
Ensembl	ENSG00000135914	ENSMUSG00000026228
UniProt	P41595	Q02152
mRNA​序列	NM_000867 ​NM_001320758	NM_008311
蛋白序列	NP_000858 ​NP_001307687	NP_032337
基因位置​（UCSC）	Chr 2: 231.11 – 231.13 Mb	Chr 1: 86.03 – 86.04 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

参见

• 5-羟色胺受体