CCL5

CCL5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Identifikatori
Aliasi	CCL5
Vanjski ID-jevi	OMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	35,880,793 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	83,421,344 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• CCR5 chemokine receptor binding; • receptor signaling protein tyrosine kinase activator activity; • chemokine activity; • protein self-association; • CCR4 chemokine receptor binding; • phosphatidylinositol phospholipase C activity; • protein kinase activity; • cytokine activity; • CCR1 chemokine receptor binding; • phospholipase activator activity; • chemokine receptor binding; • protein homodimerization activity; • chemokine receptor antagonist activity; • GO:0001948, GO:0016582 vezivanje za proteine; • chemoattractant activity; • vezivanje identičnih proteina; • CCR chemokine receptor binding;
Ćelijska komponenta	• citoplazma; • extracellular region; • Vanćelijsko;
Biološki proces	• leukocyte cell-cell adhesion; • positive regulation of cell-cell adhesion mediated by integrin; • regulation of T cell activation; • positive regulation of smooth muscle cell migration; • activation of phospholipase D activity; • negative regulation of viral genome replication; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of innate immune response; • cellular response to interferon-gamma; • positive regulation of macrophage chemotaxis; • calcium ion transport; • Egzocitoza; • positive regulation of calcium ion transport; • response to cytokine; • regulation of insulin secretion; • chemokine-mediated signaling pathway; • positive regulation of cellular biosynthetic process; • response to virus; • positive regulation of monocyte chemotaxis; • cellular response to fibroblast growth factor stimulus; • neutrophil chemotaxis; • response to tumor necrosis factor; • negative regulation of T cell apoptotic process; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • negative regulation of macrophage apoptotic process; • positive regulation of T cell proliferation; • positive regulation of phosphorylation; • inflammatory response; • positive regulation of translational initiation; • response to toxic substance; • positive regulation of epithelial cell proliferation; • positive regulation of tyrosine phosphorylation of STAT protein; • GO:1904579 cellular response to organic cyclic compound; • cellular calcium ion homeostasis; • protein tetramerization; • Hemotaksija; • positive regulation of homotypic cell-cell adhesion; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of viral genome replication; • positive regulation of receptor signaling pathway via JAK-STAT; • lipopolysaccharide-mediated signaling pathway; • positive regulation of T cell migration; • regulation of chronic inflammatory response; • positive regulation of smooth muscle cell proliferation; • neutrophil activation; • protein kinase B signaling; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • cell-cell signaling; • eosinophil chemotaxis; • dendritic cell chemotaxis; • MAPK cascade; • macrophage chemotaxis; • positive regulation of T cell chemotaxis; • regulation of neuron death; • positive regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of G protein-coupled receptor signaling pathway; • positive regulation of T cell apoptotic process; • positive regulation of cell adhesion; • negative regulation of chemokine-mediated signaling pathway; • monocyte chemotaxis; • positive chemotaxis; • positive regulation of protein tyrosine kinase activity; • cellular response to tumor necrosis factor; • positive regulation of activation of Janus kinase activity; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • lymphocyte chemotaxis;
	Izvori:Amigo / QuickGO
Ortolozi
	6352
	20304
	ENSG00000271503; ENSG00000274233
	ENSMUSG00000035042
	P13501
	P30882
	NM_002985; NM_001278736
	NM_013653
	NP_001265665; NP_002976
	NP_038681
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski
(C-C motivni)
ligand 5
(CCL5) je protein koji je kod ljudi kodiran genom CCL5.^[5] Poznat je i pod nazivom RANTES (reguliran aktivacijom, normalni T ćelija-eksprimirani i lučeni).

Kratke činjenice Dostupne strukture, PDB ...

Dužina polipeptidnog lanca je 91 aminokiselina, a molekulska težina 9.990 Da.^[6]

Sekvenca

[5]

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[3]

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[6]

CCL5

Vanjski linkovi

Wikiwand - on