Katepsin L2

CTSV
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1FH0, 3H6S, 3KFQ
Identifikatori
Aliasi	CTSV, katepsin L2, katepsin V, CATL2, CTSL2, CTSU
Vanjski ID-jevi	OMIM: 603308 MGI: 88564 HomoloGene: 76699 GeneCards: CTSV
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	97,156,556 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	64,518,704 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cysteine-type peptidase activity; • peptide binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • aminopeptidase activity; • hydrolase activity; • serine-type endopeptidase activity; • cysteine-type endopeptidase activity; • cysteine-type carboxypeptidase activity; • GO:0031493 histone binding; • kininogen binding; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• citoplazma; • perikaryon; • apical part of cell; • secretory granule; • extracellular region; • microvillus; • Vakuola; • lysosomal lumen; • neuron projection; • Lizozom; • external side of plasma membrane; • Vanćelijsko; • jedro; • Jedarce; • GO:0016023 citoplazmatska vezikula;
Biološki proces	• male gonad development; • GO:1904578 response to organic cyclic compound; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • cellular response to starvation; • extracellular matrix disassembly; • response to glucocorticoid; • response to glucose; • Sertoli cell differentiation; • response to gonadotropin; • Proteoliza; • cell communication; • decidualization; • Spermatogeneza; • multicellular organism aging; • proteolysis involved in cellular protein catabolic process; • nerve development; • autophagic cell death; • response to odorant; • regulation of keratinocyte differentiation; • negative regulation of keratinocyte proliferation; • protein processing; • protein autoprocessing; • hair follicle morphogenesis; • regulation of actin cytoskeleton reorganization;
	Izvori:Amigo / QuickGO
Ortolozi
	1515
	13039
	ENSG00000136943
	ENSMUSG00000021477
	O60911
	P06797
	NM_001333; NM_001201575
	NM_009984
	NP_001188504; NP_001324
	NP_034114
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Katepsin L2, poznat i kao katepsin V je genetički kodiran sa lokusa gena CTSL2. Ovaj protein i gen koji ga kontrolira su specifičnoat čovjeka.^[5]

Kratke činjenice CTSV, Dostupne strukture ...

Protein koji je kodiran ovim genom je član proteinske porodice peptidaza, porodica C1. To je lizosomna cistein proteinaza koja može imati važnu ulogu u fiziologiji rožnjaće.

Ovaj gen se ispoljava kod bolesnika sa karcinomima debelo crijevo i dojke, crijeva, mliječnih žlijezda ili peritumorskih tkiva. To sugerira moguću ulogu ovog gena tumorskim procesima.^[6]^[7] ^[8]^[9]

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Katepsin L2

Klinički značaj

Reference

Vanjski linkovi

Wikiwand - on