SMARCA1

Vjerovatni globalni transcripcijski aktivator SNF2L1 jest protein koji je kod ljudi kodiran genom SMARCA1.^[5][6][7]

SMARCA1
Identifikatori
Aliasi	SMARCA1
Vanjski ID-jevi	OMIM: 300012 MGI: 1935127 HomoloGene: 55711 GeneCards: SMARCA1
Lokacija gena (čovjek) Hrom. Hromosom X[1] Bend Xq25-q26.1 Početak 129,446,501 bp[1] Kraj 129,523,500 bp[1]
Lokacija gena (miš) Hrom. Hromosom X (miš)[2] Bend X|X A4 Početak 46,898,245 bp[2] Kraj 46,981,851 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • ATP-dependent DNA/DNA annealing activity • vezivanje sa DNK • nucleotide binding • ATP-dependent activity, acting on DNA • GO:0008026 helicase activity • GO:0102490, GO:0102491, GO:0102489, GO:0102488, GO:0102487, GO:0102486, GO:0102485 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • GO:0001948, GO:0016582 vezivanje za proteine • nucleic acid binding • nucleosome binding • hydrolase activity • ATP binding • transcription factor binding • ATPase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • CERF complex • jedro • nukleoplazma • intracellular membrane-bounded organelle • NURF complex Biološki proces • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • brain development • neuron differentiation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6594	93761
Ensembl	ENSG00000102038	ENSMUSG00000031099
UniProt	P28370	Q6PGB8
RefSeq (mRNK)	NM_001282874 NM_001282875 NM_003069 NM_139035 NM_001378261 NM_001378262 NM_001378263 NM_001378264	NM_001290708 NM_053123 NM_001358618 NM_001358619
RefSeq (bjelančevina)	NP_001269803 NP_001269804 NP_003060 NP_001365190 NP_001365191 NP_001365192 NP_001365193	NP_001277637 NP_444353 NP_001345547 NP_001345548
Lokacija (UCSC)	Chr X: 129.45 – 129.52 Mb	Chr X: 46.9 – 46.98 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein koji je kodiran ovim genom član je porodice proteina SWI/SNF. Članovi ove porodice imaju helikazne i ATPaznu aktivnost i smatra se da reguliraju transkripciju određenih gena mijenjajući strukturu hromatina oko njih. Za ovaj gen pronađene su dvije varijante transkripta koje kodiraju različite izoforme.^[7]