4-Aminosalicylic acid
Anti-tuberculosis and anti-inflammatory drug / From Wikipedia, the free encyclopedia
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4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) and sold under the brand name Paser among others, is an antibiotic primarily used to treat tuberculosis.[1] Specifically it is used to treat active drug resistant tuberculosis together with other antituberculosis medications.[2] It has also been used as a second line agent to sulfasalazine in people with inflammatory bowel disease such as ulcerative colitis and Crohn's disease.[2] It is typically taken by mouth.[2]
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Trade names | Paser, Granupas, others |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth |
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Protein binding | 50–60% |
Metabolism | liver |
Excretion | kidney |
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ECHA InfoCard | 100.000.557 |
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Formula | C7H7NO3 |
Molar mass | 153.137 g·mol−1 |
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Melting point | 150.5 °C (302.9 °F) |
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Common side effects include nausea, abdominal pain, and diarrhea.[2] Other side effects may include liver inflammation and allergic reactions.[2] It is not recommended in people with end stage kidney disease.[2] While there does not appear to be harm with use during pregnancy it has not been well studied in this population.[2] 4-Aminosalicylic acid is believed to work by blocking the ability of bacteria to make folic acid.[2]
4-Aminosalicylic acid was first made in 1902, and came into medical use in 1943.[3] It is on the World Health Organization's List of Essential Medicines.[4]