GPR114

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.^[5][6][7] GPR114 is a member of the adhesion GPCR family.^[8][9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[10]

ADGRG5
Identifiers
Aliases	ADGRG5, PGR27, GPR114, adhesion G protein-coupled receptor G5
External IDs	OMIM: 616965; MGI: 2685955; HomoloGene: 17828; GeneCards: ADGRG5; OMA:ADGRG5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,542,643 bp[1] End 57,591,681 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 95,650,322 bp[2] End 95,669,908 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood testicle islet of Langerhans spleen bone marrow cells appendix epithelium of nasopharynx tonsil Top expressed in mesenteric lymph nodes secondary oocyte primary oocyte spleen embryo thymus jejunum zygote blood subcutaneous adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221188 382045 Ensembl ENSG00000159618 ENSMUSG00000061577 UniProt Q8IZF4 Q3V3Z3 RefSeq (mRNA) NM_001304376 NM_153837 NM_001318481 NM_001033468 NM_001145972 RefSeq (protein) NP_001291305 NP_001305410 NP_722579 NP_001028640 NP_001139444 Location (UCSC) Chr 16: 57.54 – 57.59 Mb Chr 8: 95.65 – 95.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tissue distribution

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.^[11]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gα_s protein.^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000159618 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061577 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR114 G protein-coupled receptor 114".
6. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
7. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
8. Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
9. Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
10. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
11. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
12. Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (April 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–1219. Bibcode:2012FEBSL.586.1214G. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. S2CID 3020230.

External links

• Adhesion GPCR consortium