JAM2

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.^[5][6][7] JAM2 has also been designated as CD322 (cluster of differentiation 322).

JAM2
Identifiers
Aliases	JAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM, junctional adhesion molecule 2, IBGC8
External IDs	OMIM: 606870; MGI: 1933820; HomoloGene: 10929; GeneCards: JAM2; OMA:JAM2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 25,639,258 bp[1] End 25,717,562 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 84,571,011 bp[2] End 84,622,816 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone tendon of biceps brachii vena cava internal globus pallidus ganglionic eminence pericardium gastric mucosa body of uterus epithelium of colon tibial nerve Top expressed in interventricular septum myocardium of ventricle cumulus cell right ventricle cardiac muscles neural layer of retina deep cerebellar nuclei iris epithelium of lens substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane membrane bicellular tight junction Biological process negative regulation of cell adhesion extracellular matrix organization leukocyte migration cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58494 67374 Ensembl ENSG00000154721 ENSMUSG00000053062 UniProt P57087 Q9JI59 RefSeq (mRNA) NM_001270407 NM_001270408 NM_021219 NM_023844 RefSeq (protein) NP_001257336 NP_001257337 NP_067042 NP_076333 Location (UCSC) Chr 21: 25.64 – 25.72 Mb Chr 16: 84.57 – 84.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.^[7]

It is purported to promote lymphocyte transendothelial migration.^[8] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.^[9]

Interactions

JAM2 has been shown to interact with PARD3.^[9]

It also interacts with the integrin dimer VLA-4 (also called α4β1).^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000154721 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053062 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem. 275 (25): 19139–45. doi:10.1074/jbc.M003189200. PMID 10779521.
6. Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem. 275 (44): 34750–6. doi:10.1074/jbc.M002718200. PMID 10945976.
7. "Entrez Gene: JAM2 junctional adhesion molecule 2".
8. Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood. 100 (7): 2479–86. doi:10.1182/blood-2001-11-0098. PMID 12239159.
9. Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
10. Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135.

Further reading

• Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends Immunol. 24 (6): 327–34. doi:10.1016/S1471-4906(03)00117-0. PMID 12810109.
• Bazzoni G (2004). "The JAM family of junctional adhesion molecules". Curr. Opin. Cell Biol. 15 (5): 525–30. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Arrate MP, Rodriguez JM, Tran TM, et al. (2002). "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor". J. Biol. Chem. 276 (49): 45826–32. doi:10.1074/jbc.M105972200. PMID 11590146.
• Liang TW, Chiu HH, Gurney A, et al. (2002). "Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3". J. Immunol. 168 (4): 1618–26. doi:10.4049/jimmunol.168.4.1618. PMID 11823489.
• Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
• Cunningham SA, Rodriguez JM, Arrate MP, et al. (2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135.
• Aurrand-Lions M, Johnson-Leger C, Lamagna C, et al. (2004). "Junctional adhesion molecules and interendothelial junctions". Cells Tissues Organs (Print). 172 (3): 152–60. doi:10.1159/000066967. PMID 12476045. S2CID 34211576.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ebnet K, Aurrand-Lions M, Kuhn A, et al. (2004). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

External links

• JAM2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q9JI59 (Mouse Junctional adhesion molecule B) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.