PARD3

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.^[5][6]

PARD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KOM
Identifiers
Aliases	PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
External IDs	OMIM: 606745; MGI: 2135608; HomoloGene: 10489; GeneCards: PARD3; OMA:PARD3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.22-p11.21 Start 34,109,560 bp[1] End 34,815,325 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E2|8 74.66 cM Start 127,790,643 bp[2] End 128,338,767 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte skin of abdomen skin of leg buccal mucosa cell gingival epithelium nipple mucosa of pharynx Achilles tendon internal globus pallidus gastric mucosa Top expressed in esophagus lip tail of embryo secondary oocyte conjunctival fornix transitional epithelium of urinary bladder genital tubercle ventricular zone hand cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein phosphatase binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding identical protein binding phosphatidylinositol binding Cellular component cytoplasm cytosol membrane cell-cell junction bicellular tight junction plasma membrane axonal growth cone internode region of axon cell junction soma cell cortex cytoskeleton endomembrane system adherens junction protein-containing complex apical plasma membrane apical junction complex Biological process establishment of epithelial cell polarity cell differentiation axonogenesis protein targeting to membrane negative regulation of peptidyl-threonine phosphorylation myelination in peripheral nervous system cell division establishment or maintenance of cell polarity positive regulation of myelination regulation of cellular localization protein kinase C-activating G protein-coupled receptor signaling pathway asymmetric cell division bicellular tight junction assembly cell cycle transforming growth factor beta receptor signaling pathway protein-containing complex assembly microtubule cytoskeleton organization cell adhesion protein localization establishment of cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment of centrosome localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56288 93742 Ensembl ENSG00000148498 ENSMUSG00000025812 UniProt Q8TEW0 Q99NH2 RefSeq (mRNA) NM_001184785 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619 NM_001013580 NM_001013581 NM_001122850 NM_033620 NM_001309391 NM_001309392 NM_001363431 NM_001363432 RefSeq (protein) NP_001171714 NP_001171715 NP_001171716 NP_001171717 NP_001171718 NP_001171719 NP_001171720 NP_001171721 NP_001171722 NP_001171723 NP_062565 NP_001013598 NP_001013599 NP_001116322 NP_001296320 NP_001296321 NP_296369 NP_001350360 NP_001350361 Location (UCSC) Chr 10: 34.11 – 34.82 Mb Chr 8: 127.79 – 128.34 Mb PubMed search [3] [4]
Wikidata
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Function

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]^[6]

Interactions

PARD3 has been shown to interact with:

• JAM2,^[7]
• JAM3,^[7]
• PRKCI,^[8] and
• PVRL3.^[9]