Podophyllotoxin
Chemical compound / From Wikipedia, the free encyclopedia
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Podophyllotoxin (PPT) is the active ingredient in Podofilox, which is a medical cream that is used to treat genital warts and molluscum contagiosum.[2] It is not recommended in HPV infections without external warts.[2] It can be applied either by a healthcare provider or the person themselves.[2]
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Trade names | Condylox,[1] Wartec, others |
Other names | (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d] [1,3]dioxol-6(5aH)-one |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684055 |
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Elimination half-life | 1.0 to 4.5 hours. |
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ECHA InfoCard | 100.007.502 |
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Formula | C22H22O8 |
Molar mass | 414.410 g·mol−1 |
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Melting point | 183.3 to 184 °C (361.9 to 363.2 °F) |
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It is a non-alkaloid toxin lignin extracted from the roots and rhizomes of Podophyllum species.[3] A less refined form known as podophyllum resin is also available, but has greater side effects.[4][5]
Podophyllotoxin was first isolated in pure form in 1880 by Valerian Podwyssotzki (1818 – 28 January 1892), a Polish-Russian privatdozent at the University of Dorpat (now: Tartu, Estonia) and assistant at the Pharmacological Institute there.[6][7][8]
It is on the World Health Organization's List of Essential Medicines.[9]