YWHAB

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.^[5]

YWHAB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BQ0, 2C23, 4DNK
Identifiers
Aliases	YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
External IDs	OMIM: 601289; MGI: 1891917; HomoloGene: 20724; GeneCards: YWHAB; OMA:YWHAB - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,885,702 bp[1] End 44,908,532 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 163,836,880 bp[2] End 163,860,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus lateral nuclear group of thalamus entorhinal cortex parietal lobe postcentral gyrus pons pars compacta superior frontal gyrus Top expressed in substantia nigra ventromedial nucleus external carotid artery internal carotid artery motor neuron saccule facial motor nucleus barrel cortex anterior amygdaloid area dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein domain specific binding protein-containing complex binding histone deacetylase binding phosphoprotein binding protein C-terminus binding protein binding enzyme binding phosphoserine residue binding cadherin binding identical protein binding Cellular component cytoplasm membrane focal adhesion melanosome transcription repressor complex perinuclear region of cytoplasm extracellular exosome cytoplasmic vesicle membrane nucleus mitochondrion cytosol protein-containing complex vacuole vacuolar membrane Biological process protein targeting negative regulation of protein dephosphorylation protein heterooligomerization regulation of mRNA stability positive regulation of catalytic activity hippo signaling cytoplasmic sequestering of protein MAPK cascade positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway membrane organization viral process negative regulation of transcription, DNA-templated negative regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7529 54401 Ensembl ENSG00000166913 ENSMUSG00000018326 UniProt P31946 Q4VY19 Q9CQV8 RefSeq (mRNA) NM_139323 NM_003404 NM_018753 RefSeq (protein) NP_003395 NP_647539 NP_061223 Location (UCSC) Chr 20: 44.89 – 44.91 Mb Chr 2: 163.84 – 163.86 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.^[6]

Interactions

YWHAB has been shown to interact with:

• BRAF,^[7][8]
• C-Raf,^{[9][10][11][12][13][14]}
• CD29,^[15]
• CDC25A,^[9]
• CDC25B,^[9][16]
• Cbl gene,^[17]
• EPB41L3,^[7][18]
• HDAC4^[19]
• KCNK3,^[20]
• MAPK7,^[21]
• PTPN3,^[22]
• PRKCZ,^[12]
• RPS6KA1,^[23]
• TESK1,^[24]
• TNFAIP3,^[14] and
• WEE1.^[25]

See also

• 14-3-3 proteins