1F-LSD

1F-LSD, or 1-formyl-LSD, also known as 1-formyl-N,N-diethyllysergamide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).^[1][2] It is the 1-formyl derivative of LSD.^[1][2][3]

1F-LSD

Clinical data
Other names	1-Formyl-LSD; 1-Formyl-N,N-diethyllysergamide; N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Routes of administration	Oral; Sublingual
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None
Identifiers
IUPAC name N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide
Chemical and physical data
Formula	C21H25N3O2
Molar mass	351.450 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C=O)CC
InChI InChI=1S/C21H25N3O2/c1-4-23(5-2)21(26)15-9-17-16-7-6-8-18-20(16)14(12-24(18)13-25)10-19(17)22(3)11-15/h6-9,12-13,15,19H,4-5,10-11H2,1-3H3/t15-,19-/m1/s1 Key:SSEPNHFOVYUBHO-DNVCBOLYSA-N

The drug is assumed to act as a prodrug of LSD.^[1] It produces psychedelic effects in humans similarly to LSD.^[2] Effective doses have been reported to be 100 to 150 μg orally or sublingually.^[2] Very little is known about the pharmacology and properties of 1F-LSD.^[1]

1F-LSD was first described in the scientific literature by 2021.^[2] It first emerged as a novel designer drug online in January 2019.^[1][2]

Another compound, 1‐(furan‐2‐carbonyl)‐LSD (SYN-L-005), has also been referred to as "1F-LSD".^[3]

See also

• Substituted lysergamide