1T-LSD

1T-LSD, also known as 1-(thiophene-2-carbonyl)-LSD or as SYN-L-021, is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug. It was first identified in Japan in 2023 on blotter paper misrepresented as containing 1D-LSD, but which on analysis was determined to contain 1T-LSD instead.^[1] It was also detected in Germany around the same time.^[2]

1T-LSD

Clinical data
Other names	1-(Thiophene-2-carbonyl)-LSD; SYN-L-021
Routes of administration	By mouth, under the tongue
Identifiers
IUPAC name (6aR,9R)-N,N-diethyl-7-methyl-4-(thiophen-2-yl)methanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number	3028949-85-8 Y
PubChem CID	170763788
ChemSpider	129341136
Chemical and physical data
Formula	C25H27N3O2S
Molar mass	433.57 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(n1cc2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)c3cccc1c32)c1cccs1

Use and effects

See also: LSD § Uses, and LSD § Effects

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Analogues

Analogues of 1T-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1V-LSD, 1DD-LSD, and 1T-AL-LAD, among others.

See also

• Substituted lysergamide
• Lizard Labs