1H-LSD

1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027,^[1] is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position. It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.^[2]

1H-LSD

Clinical data
Other names	1-Hexanoyl-LSD; SYN-L-027
Legal status
Legal status	DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Unscheduled (may be covered by the Federal Analogue Act if sold for human consumption) UN: Unscheduled
Identifiers
IUPAC name (6aR,9R)-N,N-diethyl-6-methyl-4-hexanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
PubChem CID	170763690
Chemical and physical data
Formula	C26H35N3O2
Molar mass	421.585 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CC(C=C2[C@H]1Cc1cn(C(=O)CCCCC)c3cccc2c31)C(=O)N(CC)CC
InChI InChI=InChI=1S/C26H35N3O2/c1-5-8-9-13-24(30)29-17-18-15-23-21(20-11-10-12-22(29)25(18)20)14-19(16-27(23)4)26(31)28(6-2)7-3/h10-12,14,17,19,23H,5-9,13,15-16H2,1-4H3/t19?,23-/m1/s1 Key:RSBBZALMPUUEKF-LEQGEALCSA-N

Use and effects

See also: LSD § Uses, and LSD § Effects

1H-LSD produces similar effects to LSD with a shorter metabolic half-life.^{[citation needed]} There are no documented cases of it being used recreationally.^[3]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Analogues

Analogues of 1H-LSD include ALD-52 (1A-LSD), 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.

See also

• Substituted lysergamide
• Lizard Labs