1V-LSD

1V-LSD, also known as 1-valeryl-LSD or by the nickname Valerie, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).^[1][2] It is an analogue of LSD and is thought to act as a prodrug of LSD.^[3]

1V-LSD

Clinical data
Other names	1-Valeryl-LSD; 1-Valeroyl-LSD; 1-Pentanoyl-LSD; Valerie; 1-Valeryl-N,N-diethyllysergamide
Routes of administration	Oral
Legal status
Legal status	AU: S8 (Controlled drug) CA: Unscheduled DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Unscheduled (when wasn't sold for human consumption) UN: Unscheduled
Identifiers
IUPAC name (6aR,9R)-N,N-Diethyl-7-methyl-4-pentanoyl-4,,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number	3028950-70-8
PubChem CID	162368540
UNII	V9TJ3HT283
CompTox Dashboard (EPA)	DTXSID801342453
Chemical and physical data
Formula	C25H33N3O2
Molar mass	407.558 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)CCCC)c4cccc2c34)N(C)C5
InChI InChI=1S/C25H33N3O2/c1-5-8-12-23(29)28-16-17-14-22-20(19-10-9-11-21(28)24(17)19)13-18(15-26(22)4)25(30)27(6-2)7-3/h9-11,13,16,18,22H,5-8,12,14-15H2,1-4H3/t18-,22-/m1/s1 Key:GIIBVGJWUZNECE-XMSQKQJNSA-N

1V-LSD has been sold online until an amendment to the German NpSG was enforced in 2022 which controls 1P-LSD and now 1cP-LSD, 1V-LSD and several other lysergamides.^[4]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act directly as a weak partial agonist at the serotonin 5-HT_2A receptor.^[3]

A head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.^[5]

Chemistry

Synthesis

1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.^[6]

Detection

Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules.^[7] However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.^[8][9]

Analogues

Related compounds include 1B-LSD, 1cP-LSD, 1D-LSD, 1P-LSD, and AL-LAD, among others.

Society and culture

Legal status

1v-LSD strip blotters.

Germany

An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.^[10] The law was amended in March 2023, now banning 1V-LSD.

North America

1V-LSD is not a controlled substance in North America (United States and Canada), unless sold for human consumption in the US.^[11]

South Korea

1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.^[12]

Sweden

Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.

See also

• Substituted lysergamide
• Lizard Labs