2'-5'-oligoadenylate synthase

In molecular biology, 2'-5'-oligoadenylate synthetase (2-5A synthetase) is an enzyme (EC 2.7.7.84) that reacts to interferon signal. It is an antiviral enzyme that counteracts viral attack by degrading RNAs, both viral and host. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'-5'-oligoadenylates, which activate latent ribonuclease (RNase-L), resulting in degradation of viral RNA and inhibition of virus replication.^[1]

2'-5'-oligoadenylate synthetase
Pig 2'-5'-oligoadenylate synthetase, N- and C-terminal domains coloured red and blue, respectively. PDB: 1PX5​
Identifiers
Symbol	OAS1_C
Pfam	PF10421
InterPro	IPR018952
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The C-terminal half of 2'-5'-oligoadenylate synthetase, also referred to as domain 2 of the enzyme, is largely alpha-helical and homologous to a tandem ubiquitin repeat. It carries the region of enzymatic activity between^{[clarification needed]} at the extreme C-terminal end.^[2]

Human proteins

• OAS1
• OAS2
• OAS3

See also

• OASL