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2-Oxo-3-hydroxy-LSD
Pharmaceutical compound From Wikipedia, the free encyclopedia
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2-Oxo-3-hydroxy-LSD, or 2-oxy-3-hydroxy-LSD, also known as O-H-LSD or OH-LSD, as well as more fully as 2-oxo-3-hydroxy-2,3-dihydro-LSD, is a lysergamide and the major metabolite of the psychedelic drug lysergic acid diethylamide (LSD).[1][2][3][4] LSD is eliminated 13% as O-H-LSD in urine within 24 hours[5] and urinary concentrations of O-H-LSD are 4 to 40 times those of LSD in humans.[6][3][7][8]
The specific enzymes responsible for the formation of O-H-LSD from LSD are unclear.[5][7][8][3] However, subsequent research found involvement of several cytochrome P450 enzymes.[9] O-H-LSD is thought to form from other LSD metabolites like 2-oxo-LSD and 3-hydroxy-LSD.[6][3][7][8][10]
It is unknown whether O-H-LSD is pharmacologically active.[5] However, O-H-LSD showed profoundly reduced albeit still detectable activity at the serotonin 5-HT2 receptors, including the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, compared to LSD in vitro.[9]
O-H-LSD was first described in the scientific literature by at least the 1990s.[11][12]
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