2C-Se-TFM

2C-Se-TFM is a designer drug from the substituted phenethylamine family, which produces psychedelic-like effects in animals such as a head twitch response. It was first synthesised by Josh Hartsel and colleagues in 2024. It has a binding affinity (K_i) of 3.2 nM at the serotonin receptor 5-HT_2A and an EC₅₀ of 3.6 nM, acting as a full agonist. Aside from 2C-Se, it is the only psychedelic drug containing a selenium atom, as while other related analogues such as the ethyl compound 2C-Se-2 and the propyl derivative 2C-Se-7 have been proposed as theoretical compounds, neither is known to have been synthesised.^[1][2]

2C-Se-TFM

Identifiers
IUPAC name 4-trifluoromethylselanyl-2,5-dimethoxyphenethylamine
PubChem CID	171534638
Chemical and physical data
Formula	C11H14F3NO2Se
Molar mass	328.204 g·mol−1
3D model (JSmol)	Interactive image
SMILES NCCc1cc(OC)c(cc1OC)[Se]C(F)(F)F
InChI InChI=1S/C11H14F3NO2Se/c1-16-8-6-10(18-11(12,13)14)9(17-2)5-7(8)3-4-15/h5-6H,3-4,15H2,1-2H3 Key:ODGBUUUVMLDZBP-UHFFFAOYSA-N

See also

• 2C-TFE
• 2C-T-4
• 2C-T-21
• 2C-T-TFM
• 2C-Te