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2C-tBu

Pharmaceutical compound From Wikipedia, the free encyclopedia

2C-tBu
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2C-tBu, or 2C-t-Bu, also known as 4-tert-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor agonist and putative serotonergic psychedelic of the phenethylamine and 2C families.[1][2]

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It is a potent serotonin 5-HT2A receptor agonist (Ki = 9.9–35 nM, EC50Tooltip half-maximal effective concentration = 4.2 nM) and also binds to the serotonin 5-HT2C receptor (Ki = 7–24 nM).[1][2] The drug produces a robust head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[2] It also produces hyperlocomotion in rodents.[2]

The active dosage in humans is >5 mg per Daniel Trachsel and its duration is unknown.[1] Initial tests with 7 mg and with 10 mg (as 5 mg plus 5 mg 2 hours apart) produced no psychedelic effects in humans, but instead induced a pronounced and long-lasting tiredness.[1]

It was hypothesized that 2C-tBu might be a serotonin 5-HT2A receptor antagonist and might thereby be hypnotic,[1] but it was instead shown to be an agonist in subsequent studies.[2]

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