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2C-Bu
Pharmaceutical compound From Wikipedia, the free encyclopedia
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2C-Bu, also known as 4-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and 2C families.[1][2] It is the 2C analogue of the DOx derivative DOBU.[1][3][4]
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Use and effects
2C-Bu was not included in Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved) and its properties and effects in humans are unknown.[3][1]
Pharmacology
Pharmacodynamics
2C-Bu is a potent and high-efficacy serotonin 5-HT2A receptor partial agonist, with an EC50 of 3.9 to 29 nM and an Emax of 71 to 93%.[2]
Chemistry
Analogues
2C-Bu follows 2C-D, 2C-E, and 2C-P in the homologous series of 4-alkylated 2C derivatives.[1] Higher homologues of 2C-Bu including 2C-Am and 2C-Hx are also known and have been characterized.[2]
2C-Bu has several notable skeletal isomers, including 2C-iBu, 2C-tBu, and 2C-sBu.[1][5] 2C-iBu and 2C-tBu are both active and produce hallucinogen-type effects in animals and/or humans.[6][7][8][5] This is in spite of 2C-tBu being predicted to be inactive[5] and DOTB (the DOx analogue of 2C-tBu) being inactive as a hallucinogen in animals and humans.[3][9] 2C-iBu may have reduced hallucinogenic potency than other 2C drugs and is being developed as a potential anti-inflammatory medication.[7][8]
History
2C-Bu was said by Daniel Trachsel and colleagues in 2013 to be completely unknown.[1] However, the drug was subsequently characterized in 2025.[2]
See also
References
External links
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