2C-Bu

2C-Bu, also known as 4-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and 2C families.^[1][2] It was said by Daniel Trachsel in 2013 to be completely unknown.^[1] However, the drug was subsequently characterized in 2025.^[2] 2C-Bu is the 2C analogue of the DOx derivative DOBU.^[1][3][4]

2C-Bu

Clinical data
Other names	4-Butyl-2,5-dimethoxyphenethylamine; 2,5-Dimethoxy-4-butylphenethylamine; 2C-BU
Drug class	Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist
ATC code	None
Identifiers
IUPAC name 2-(4-butyl-2,5-dimethoxyphenyl)ethan-1-amine
CAS Number	2888537-44-6
PubChem CID	172187929
Chemical and physical data
Formula	C14H23NO2
Molar mass	237.343 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCC1=CC(=C(C=C1OC)CCN)OC
InChI InChI=1S/C14H23NO2/c1-4-5-6-11-9-14(17-3)12(7-8-15)10-13(11)16-2/h9-10H,4-8,15H2,1-3H3 Key:WVGDKSDIKCPRKV-UHFFFAOYSA-N

The drug is a potent and high-efficacy serotonin 5-HT_2A receptor partial agonist, with an EC₅₀Tooltip half-maximal effective concentration of 3.9 to 29 nM and an E_maxTooltip maximal efficacy of 71 to 93%.^[2]

2C-Bu has several notable skeletal isomers, including 2C-iBu, 2C-tBu, and 2C-sBu.^[1][5] 2C-iBu and 2C-tBu are both active and produce hallucinogen-type effects in animals and/or humans.^[6][7][8][5] This is in spite of 2C-tBu being predicted to be inactive^[5] and DOTB (the DOx analogue of 2C-tBu) being inactive as a hallucinogen in animals and humans.^[3][9] 2C-iBu may have reduced hallucinogenic potency than other 2C drugs and is being developed as a potential anti-inflammatory medication.^[7][8]

Higher homologues of 2C-Bu including 2C-Am and 2C-Hx are also known and have been characterized.^[2]

See also

• 2C (psychedelics)
• 2C-P
• 2C-CP
• 2C-CPE