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5-APBT
Pharmaceutical compound From Wikipedia, the free encyclopedia
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5-(2-Aminopropyl)-1-benzothiophene (5-APBT) is a monoamine releasing agent and serotonin receptor agonist of the amphetamine and benzothiophene families.[1][2] It is related to MDA and other MDA bioisosteres like the benzofurans.[1][2]
The drug acts as a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA) and full agonist of the serotonin 5-HT2 receptors.[2] It has approximately 4- and 9-fold preference for induction of serotonin release over norepinephrine and dopamine release, respectively, in rat brain synaptosomes.[2] 5-APBT does not increase locomotor activity in rodents and hence does not appear to have stimulant-like effects.[2] However, it does produce the head-twitch response, a behavioral proxy of psychedelic effects, and hence may have hallucinogenic effects.[2]
5-APBT was first described in the scientific literature by 2020.[1][2]
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