A1CF

APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene.^[5][6][7]

A1CF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CPD
Identifiers
Aliases	A1CF, ACF, ACF64, ACF65, APOBEC1CF, ASP, APOBEC1 complementation factor
External IDs	OMIM: 618199; MGI: 1917115; HomoloGene: 16363; GeneCards: A1CF; OMA:A1CF - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23 Start 50,799,409 bp[1] End 50,885,675 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 31,846,164 bp[2] End 31,926,395 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver jejunal mucosa mucosa of ileum right lobe of liver buccal mucosa cell duodenum mucosa of colon mucosa of sigmoid colon oocyte pancreatic ductal cell Top expressed in right kidney proximal tubule embryo yolk sac liver duodenum left lobe of liver lumbar subsegment of spinal cord jejunum human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding double-stranded RNA binding protein binding single-stranded RNA binding RNA binding mRNA binding Cellular component cytoplasm apolipoprotein B mRNA editing enzyme complex endoplasmic reticulum nucleus nucleoplasm Biological process mRNA processing protein stabilization cytidine to uridine editing mRNA modification mRNA localization resulting in posttranscriptional regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29974 69865 Ensembl ENSG00000148584 ENSMUSG00000052595 UniProt Q9NQ94 Q5YD48 RefSeq (mRNA) NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933 NM_001370130 NM_001370131 NM_001081074 NM_001365078 RefSeq (protein) NP_001185747 NP_001185748 NP_001185749 NP_055391 NP_620310 NP_620311 NP_001357059 NP_001357060 NP_001074543 NP_001352007 Location (UCSC) Chr 10: 50.8 – 50.89 Mb Chr 19: 31.85 – 31.93 Mb PubMed search [3] [4]
Wikidata
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Gene

Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.^[7]

Function

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC1 and a complementation factor encoded by this gene.^[8] The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.^[7]

Its deletion results in lethality in mice.^[9]

Interactions

A1CF has been shown to interact with APOBEC1,^[10][11] CUGBP2,^[12] and SYNCRIP.^[13][10]