ABHD6

alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene.

ABHD6
Identifiers
Aliases	ABHD6, abhydrolase domain containing 6, abhydrolase domain containing 6, acylglycerol lipase
External IDs	OMIM: 616966; MGI: 1913332; HomoloGene: 23246; GeneCards: ABHD6; OMA:ABHD6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 58,237,532 bp[1] End 58,295,693 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A1 Start 14,413,010 bp[2] End 14,466,871 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa lateral nuclear group of thalamus corpus callosum C1 segment endothelial cell cerebellar vermis right lobe of liver duodenum external globus pallidus Top expressed in motor neuron adrenal gland facial motor nucleus Rostral migratory stream anterior horn of spinal cord duodenum lateral geniculate nucleus dentate gyrus of hippocampal formation granule cell left lobe of liver pontine nuclei More reference expression data BioGPS n/a
Gene ontology Molecular function catalytic activity hydrolase activity acylglycerol lipase activity phospholipase activity Cellular component integral component of membrane plasma membrane AMPA glutamate receptor complex membrane mitochondrion glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane lysosomal membrane late endosome membrane lysosome endosome mitochondrial membranes Biological process acylglycerol catabolic process negative regulation of cell migration positive regulation of lipid biosynthetic process regulation of endocannabinoid signaling pathway phospholipid catabolic process long-term depression negative regulation of cold-induced thermogenesis monoacylglycerol catabolic process lysobisphosphatidic acid metabolic process lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57406 66082 Ensembl ENSG00000163686 ENSMUSG00000025277 UniProt Q9BV23 Q8R2Y0 RefSeq (mRNA) NM_020676 NM_001320126 NM_025341 NM_001331064 NM_001331065 RefSeq (protein) NP_001307055 NP_065727 NP_065727.4 NP_001307055.1 NP_001317993 NP_001317994 NP_079617 Location (UCSC) Chr 3: 58.24 – 58.3 Mb Chr 14: 14.41 – 14.47 Mb PubMed search [3] [4]
Wikidata
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Function

ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.^[5]

ABHD6 has been linked to regulation of the endocannabinoid system as it controls the accumulation of 2-arachidonoylglycerol (2-AG) at the cannabinoid receptors.^[6]

ABHD6 accounts for about 4% of 2-AG brain hydrolysis.^[7] Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control about 99% of 2-AG signalling in the brain,^[7][8] and each enzyme exhibits a distinct subcellular distribution, suggesting that they regulate distinct pools of 2-AG in the nervous system.^[9]

See also

• Fatty acid amide hydrolase