ABLIM3

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.^[5]

ABLIM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UJS, 2DJ7
Identifiers
Aliases	ABLIM3, HMFN1661, actin binding LIM protein family member 3
External IDs	OMIM: 611305; MGI: 2442582; HomoloGene: 69175; GeneCards: ABLIM3; OMA:ABLIM3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 149,141,483 bp[1] End 149,260,542 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 61,932,463 bp[2] End 62,044,895 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right auricle of heart cardiac muscle tissue of right atrium glutes cerebellar hemisphere right hemisphere of cerebellum left ventricle paraflocculus of cerebellum subcutaneous adipose tissue right lobe of liver Top expressed in lumbar spinal ganglion right lung lobe interventricular septum supraoptic nucleus trigeminal ganglion otolith organ cerebellum cerebellar cortex utricle myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding actin binding protein binding Cellular component cytoplasm stress fiber lamellipodium Biological process cytoskeleton organization actin cytoskeleton organization transcription, DNA-templated lamellipodium assembly positive regulation of transcription by RNA polymerase II positive regulation of protein targeting to mitochondrion cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22885 319713 Ensembl ENSG00000173210 ENSMUSG00000032735 UniProt O94929 Q69ZX8 RefSeq (mRNA) NM_001301015 NM_001301018 NM_001301027 NM_001301028 NM_014945 NM_001345858 NM_001345859 NM_001345860 NM_001345861 NM_001370417 NM_001370418 NM_001164491 NM_198649 NM_001360868 RefSeq (protein) NP_001287944 NP_001287947 NP_001287957 NP_001332787 NP_001332788 NP_001332789 NP_001332790 NP_055760 NP_001357346 NP_001357347 NP_001157963 NP_941051 NP_001347797 Location (UCSC) Chr 5: 149.14 – 149.26 Mb Chr 18: 61.93 – 62.04 Mb PubMed search [3] [4]
Wikidata
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Function

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.^[6] An important paralog of this gene is LIMS1.

Clinical relevance

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.