ACYP1

Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.^[5][6][7]

ACYP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K7J, 2K7K, 2VH7, 2W4C, 2W4P, 3TOQ
Identifiers
Aliases	ACYP1, ACYPE, acylphosphatase 1
External IDs	OMIM: 600875; MGI: 1913454; HomoloGene: 11932; GeneCards: ACYP1; OMA:ACYP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 75,053,237 bp[1] End 75,069,483 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 85,319,172 bp[2] End 85,335,212 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lung ventricular zone ganglionic eminence pituitary gland middle temporal gyrus anterior pituitary Brodmann area 9 right lobe of thyroid gland C1 segment Top expressed in seminiferous tubule spermatocyte spermatid facial motor nucleus choroid plexus of fourth ventricle intercostal muscle lobe of cerebellum deep cerebellar nuclei cerebellar vermis medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity acylphosphatase activity Cellular component extracellular exosome Biological process phosphate-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 97 66204 Ensembl ENSG00000119640 ENSMUSG00000008822 UniProt P07311 P56376 RefSeq (mRNA) NM_001107 NM_001302616 NM_001302617 NM_203488 NM_025421 NM_001364360 NM_001364361 RefSeq (protein) NP_001098 NP_001289545 NP_001289546 NP_079697 NP_001351289 NP_001351290 Location (UCSC) Chr 14: 75.05 – 75.07 Mb Chr 12: 85.32 – 85.34 Mb PubMed search [3] [4]
Wikidata
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Function

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.^[7]