ACYP2

Acylphosphatase-2 is an enzyme that in humans is encoded by the ACYP2 gene.^[5][6]

ACYP2
Identifiers
Aliases	ACYP2, ACYM, ACYP, acylphosphatase 2
External IDs	OMIM: 102595; MGI: 1922822; HomoloGene: 41776; GeneCards: ACYP2; OMA:ACYP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.2 Start 53,970,838 bp[1] End 54,305,300 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 30,455,991 bp[2] End 30,599,587 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons biceps brachii thoracic diaphragm C1 segment Skeletal muscle tissue of rectus abdominis vastus lateralis muscle muscle of thigh body of tongue gastrocnemius muscle superior vestibular nucleus Top expressed in intercostal muscle quadriceps femoris muscle vastus lateralis muscle masseter muscle facial motor nucleus tibialis anterior muscle medial head of gastrocnemius muscle triceps brachii muscle digastric muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity acylphosphatase activity identical protein binding Cellular component mitochondrion Biological process phosphate-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 98 75572 Ensembl ENSG00000170634 ENSMUSG00000060923 UniProt P14621 P56375 RefSeq (mRNA) NM_138448 NM_001320586 NM_001320587 NM_001320588 NM_001320589 NM_001320590 NM_029344 RefSeq (protein) NP_001307515 NP_001307516 NP_001307517 NP_001307518 NP_001307519 NP_612457 NP_083620 Location (UCSC) Chr 2: 53.97 – 54.31 Mb Chr 11: 30.46 – 30.6 Mb PubMed search [3] [4]
Wikidata
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Function

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation.^[6]