ADARB2

Double-stranded RNA-specific editase B2 is an enzyme that in humans is encoded by the ADARB2 gene.^[5][6][7]

ADARB2
Identifiers
Aliases	ADARB2, ADAR3, RED2, adenosine deaminase, RNA specific B2 (inactive), adenosine deaminase RNA specific B2 (inactive)
External IDs	OMIM: 602065; MGI: 2151118; HomoloGene: 10276; GeneCards: ADARB2; OMA:ADARB2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.3 Start 1,177,313 bp[1] End 1,737,525 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 8,252,902 bp[2] End 8,818,783 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment substantia nigra Amygdala hippocampus proper corpus callosum putamen prefrontal cortex Brodmann area 9 anterior cingulate cortex Pons Top expressed in lateral geniculate nucleus medial geniculate nucleus substantia nigra zygote lumbar subsegment of spinal cord medial dorsal nucleus Rostral migratory stream dentate gyrus of hippocampal formation granule cell olfactory bulb secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function double-stranded RNA binding hydrolase activity single-stranded RNA binding metal ion binding adenosine deaminase activity RNA binding double-stranded RNA adenosine deaminase activity tRNA-specific adenosine deaminase activity Cellular component nucleus nucleolus cytoplasm Biological process mRNA processing RNA processing adenosine to inosine editing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 105 94191 Ensembl ENSG00000185736 ENSMUSG00000052551 UniProt Q9NS39 Q9JI20 RefSeq (mRNA) NM_018702 NM_001289530 NM_052977 RefSeq (protein) NP_061172 NP_001276459 NP_443209 Location (UCSC) Chr 10: 1.18 – 1.74 Mb Chr 13: 8.25 – 8.82 Mb PubMed search [3] [4]
Wikidata
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Function

RNA-editing deaminase-2 (RED2, or ADARB2) is a member of the double-stranded RNA (dsRNA) adenosine deaminase family of RNA-editing enzymes. Adenosine deamination of pre-mRNA results in a change in the amino acid sequence of the gene product, which differs from that predicted by the genomic DNA sequence. Other members of this family include DRADA (ADAR) and RED1 (ADARB1).^[5][7]

Unlike ADAR1 and ADAR2, ADAR3 has demonstrated no editing ability in vitro. It has been shown to suppress 5-HT2C RNA editing in vitro through a yet unknown mechanism, and may thus work as a negative regulator.^[8]