AKAP11

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.^[5][6][7]

AKAP11
Identifiers
Aliases	AKAP11, AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
External IDs	OMIM: 604696; MGI: 2684060; HomoloGene: 8279; GeneCards: AKAP11; OMA:AKAP11 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 42,272,152 bp[1] End 42,323,261 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 78,729,686 bp[2] End 78,774,248 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 postcentral gyrus orbitofrontal cortex Pons frontal pole lateral nuclear group of thalamus subthalamic nucleus superior frontal gyrus middle frontal gyrus Region I of hippocampus proper Top expressed in Region I of hippocampus proper substantia nigra olfactory tubercle nucleus of stria terminalis trigeminal ganglion piriform cortex anterior amygdaloid area subiculum ventromedial nucleus lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 1 binding protein kinase A binding protein binding Cellular component cytoplasm peroxisome cytoskeleton microtubule organizing center nucleolus cytosol plasma membrane Biological process intracellular signal transduction regulation of protein kinase A signaling protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11215 219181 Ensembl ENSG00000023516 ENSMUSG00000022016 UniProt Q9UKA4 n/a RefSeq (mRNA) NM_016248 NM_144490 NM_001164503 NM_001346784 RefSeq (protein) NP_057332 n/a Location (UCSC) Chr 13: 42.27 – 42.32 Mb Chr 14: 78.73 – 78.77 Mb PubMed search [3] [4]
Wikidata
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Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.^[7]

Interactions

AKAP11 has been shown to interact with:

• GSK3B,^[8]
• PPP1CA,^[8][9]
• PRKAR2A,^[6][8][10]
• PRKAR2B.^[11]
• VAPB.^[12] Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar to that found in AKAP3.^[13]

Role in bipolar disorder

AKAP11 has been identified as a definitive risk gene for bipolar disorder based on a whole-exome study of 13933 patients with bipolar disorder matched with 14422 controls.^[14]