AKR1B10

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.^[5][6][7]

AKR1B10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZUA, 4GA8, 4GAB, 4GQ0, 4GQG, 4I5X, 4ICC, 4JIH, 4JII, 4WEV, 4XZL, 4XZN, 4XZM
Identifiers
Aliases	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, aldo-keto reductase family 1, member B10 (aldose reductase), aldo-keto reductase family 1 member B10
External IDs	OMIM: 604707; MGI: 107673; HomoloGene: 116462; GeneCards: AKR1B10; OMA:AKR1B10 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 134,527,567 bp[1] End 134,541,412 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B1|6 14.91 cM Start 34,331,054 bp[2] End 34,345,398 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum gums gingival epithelium mucosa of transverse colon gallbladder pancreatic ductal cell gastric mucosa islet of Langerhans mucosa of sigmoid colon Top expressed in pyloric antrum mucous cell of stomach adrenal gland Scarpa's ganglion epithelium of stomach blastocyst endothelial cell of lymphatic vessel Gonadal ridge stroma of bone marrow duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function retinal dehydrogenase activity geranylgeranyl reductase activity indanol dehydrogenase activity aldo-keto reductase (NADP) activity protein binding oxidoreductase activity alditol:NADP+ 1-oxidoreductase activity alcohol dehydrogenase (NADP+) activity NADP-retinol dehydrogenase activity allyl-alcohol dehydrogenase activity Cellular component cytosol extracellular region lysosome mitochondrion Biological process daunorubicin metabolic process doxorubicin metabolic process retinoid metabolic process farnesol catabolic process retinol metabolic process cellular detoxification of aldehyde Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57016 14187 Ensembl ENSG00000198074 ENSMUSG00000029762 UniProt O60218 P45377 RefSeq (mRNA) NM_020299 NM_008012 RefSeq (protein) NP_064695 NP_032038 Location (UCSC) Chr 7: 134.53 – 134.54 Mb Chr 6: 34.33 – 34.35 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.^[7]