AKR7A2

Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene.^[5][6]

AKR7A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BP1
Identifiers
Aliases	AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7, aldo-keto reductase family 7, member A2, aldo-keto reductase family 7 member A2
External IDs	OMIM: 603418; MGI: 107796; HomoloGene: 2737; GeneCards: AKR7A2; OMA:AKR7A2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 19,303,965 bp[1] End 19,312,144 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 70.64 cM Start 139,038,055 bp[2] End 139,045,737 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum right adrenal gland right adrenal cortex right uterine tube left adrenal gland jejunal mucosa left adrenal cortex human kidney canal of the cervix Top expressed in right kidney proximal tubule left lobe of liver Paneth cell human kidney internal carotid artery crypt of lieberkuhn of small intestine external carotid artery right ventricle motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alditol:NADP+ 1-oxidoreductase activity electron transfer activity oxidoreductase activity phenanthrene-9,10-epoxide hydrolase activity aldo-keto reductase (NADP) activity protein binding Cellular component cytoplasm Golgi apparatus extracellular exosome cytosol Biological process xenobiotic metabolic process cellular aldehyde metabolic process daunorubicin metabolic process doxorubicin metabolic process carbohydrate metabolic process electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8574 110198 Ensembl ENSG00000053371 ENSMUSG00000028743 UniProt O43488 Q8CG76 RefSeq (mRNA) NM_003689 NM_001320979 NM_025337 RefSeq (protein) NP_001307908 NP_003680 NP_079613 Location (UCSC) Chr 1: 19.3 – 19.31 Mb Chr 4: 139.04 – 139.05 Mb PubMed search [3] [4]
Wikidata
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Function

Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM]^[6]