ANAPC10

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.^[5][6][7]

ANAPC10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JHJ, 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC10, APC10, DOC1, anaphase promoting complex subunit 10
External IDs	OMIM: 613745; MGI: 1916249; HomoloGene: 32238; GeneCards: ANAPC10; OMA:ANAPC10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 144,831,908 bp[1] End 145,098,541 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C1|8 37.79 cM Start 80,438,449 bp[2] End 80,505,688 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte Achilles tendon secondary oocyte gonad ventricular zone ganglionic eminence tibial arteries right testis left testis gastrocnemius muscle Top expressed in hand medial ganglionic eminence morula blastocyst seminiferous tubule superior cervical ganglion abdominal wall vas deferens atrioventricular valve mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity Cellular component cytoplasm nucleoplasm cytosol anaphase-promoting complex Biological process cell cycle protein ubiquitination protein K11-linked ubiquitination cell division anaphase-promoting complex-dependent catabolic process positive regulation of ubiquitin protein ligase activity regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10393 68999 Ensembl ENSG00000164162 ENSMUSG00000036977 UniProt Q9UM13 Q8K2H6 RefSeq (mRNA) NM_001256706 NM_001256707 NM_001256708 NM_001256709 NM_001256710 NM_001256711 NM_001256712 NM_014885 NM_001318367 NM_026904 NM_001357234 NM_001357235 NM_001357236 NM_001357237 RefSeq (protein) NP_001243635 NP_001243636 NP_001243637 NP_001243638 NP_001243639 NP_001243640 NP_001243641 NP_001305296 NP_055700 NP_081180 NP_001344163 NP_001344164 NP_001344165 NP_001344166 Location (UCSC) Chr 4: 144.83 – 145.1 Mb Chr 8: 80.44 – 80.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ANAPC10 has been shown to interact with CDC27,^[8][9] Mothers against decapentaplegic homolog 3^[10] and Mothers against decapentaplegic homolog 2.^[10]