CDC27

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.^[5][6]

CDC27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T1N, 4RG6, 4RG7, 4RG9, 4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	CDC27, ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2, cell division cycle 27
External IDs	OMIM: 116946; MGI: 102685; HomoloGene: 960; GeneCards: CDC27; OMA:CDC27 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,117,703 bp[1] End 47,189,422 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.79 cM Start 104,502,745 bp[2] End 104,550,620 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell tibia Achilles tendon epithelium of colon Brodmann area 23 tendon of biceps brachii internal globus pallidus stromal cell of endometrium germinal epithelium Top expressed in genital tubercle tail of embryo zygote cumulus cell secondary oocyte mandibular prominence maxillary prominence renal corpuscle pineal gland human fetus More reference expression data BioGPS n/a
Gene ontology Molecular function protein phosphatase binding protein binding Cellular component cytoplasm cytosol centrosome spindle spindle microtubule anaphase-promoting complex nucleus nucleoplasm Biological process metaphase anaphase-promoting complex-dependent catabolic process cell population proliferation protein ubiquitination protein K11-linked ubiquitination regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 996 217232 Ensembl ENSG00000004897 ENSMUSG00000020687 UniProt P30260 A2A6Q5 RefSeq (mRNA) NM_001114091 NM_001256 NM_001293089 NM_001293091 NM_001353035 NM_001353047 NM_001353049 NM_001353050 NM_001353051 NM_001285988 NM_001285989 NM_001285990 NM_145436 RefSeq (protein) NP_001107563 NP_001247 NP_001280018 NP_001280020 NP_001339964 NP_001339976 NP_001339978 NP_001339979 NP_001339980 NP_001272917 NP_001272918 NP_001272919 NP_663411 Location (UCSC) Chr 17: 47.12 – 47.19 Mb Chr 11: 104.5 – 104.55 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.^[6]

Interactions

CDC27 has been shown to interact with:

• ANAPC10,^[7][8]
• ANAPC11,^[7][8]
• ANAPC1,^[7][9]
• ANAPC4,^[7][8]
• ANAPC5,^[7][8][10]
• ANAPC7,^[7][8]
• CDC16,^{[7][8][11][12]}
• CDC20,^{[7][11][13][14][15][16][17]}
• CDC23,^[7][8]
• CDH1,^[7]
• FZR1,^[13][18]
• MAD2L1^[11][16] and
• PIN1.^[19][20]