ANAPC2

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.^[5][6]

ANAPC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 4YII, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC2, APC2, anaphase promoting complex subunit 2
External IDs	OMIM: 606946; MGI: 2139135; HomoloGene: 8359; GeneCards: ANAPC2; OMA:ANAPC2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,174,784 bp[1] End 137,188,560 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,162,490 bp[2] End 25,175,927 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum left testis right testis granulocyte left ovary right ovary skin of leg tibial nerve skin of abdomen Top expressed in internal carotid artery external carotid artery ventricular zone dermis calvaria vestibular membrane of cochlear duct utricle neural tube efferent ductule abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity ubiquitin protein ligase binding protein binding Cellular component cytosol nucleoplasm anaphase-promoting complex nucleus Biological process cell differentiation ubiquitin-dependent protein catabolic process nervous system development positive regulation of synaptic plasticity protein K11-linked ubiquitination cell division positive regulation of synapse maturation positive regulation of dendrite morphogenesis protein ubiquitination cell cycle anaphase-promoting complex-dependent catabolic process positive regulation of axon extension regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29882 99152 Ensembl ENSG00000176248 ENSMUSG00000026965 UniProt Q9UJX6 Q8BZQ7 RefSeq (mRNA) NM_013366 NM_175300 RefSeq (protein) NP_037498 NP_780509 Location (UCSC) Chr 9: 137.17 – 137.19 Mb Chr 2: 25.16 – 25.18 Mb PubMed search [3] [4]
Wikidata
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A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.^[6]

Interactions

ANAPC2 has been shown to interact with ANAPC1^[7][8] and ANAPC11.^[5][9]