ANAPC11

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.^[5][6]

ANAPC11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MT5, 4R2Y, 4UI9, 5A31, 5G04, 5JG6, 5G05
Identifiers
Aliases	ANAPC11, APC11, Apc11p, HSPC214, anaphase promoting complex subunit 11
External IDs	OMIM: 614534; MGI: 1913406; HomoloGene: 41136; GeneCards: ANAPC11; OMA:ANAPC11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,890,790 bp[1] End 81,900,991 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,489,247 bp[2] End 120,499,024 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis apex of heart temporal lobe muscle of thigh amygdala left ventricle gastrocnemius muscle right auricle of heart substantia nigra Top expressed in atrium yolk sac embryo morula efferent ductule medial ganglionic eminence optic nerve epiblast Ileal epithelium human fetus More reference expression data BioGPS n/a
Gene ontology Molecular function cullin family protein binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity ubiquitin-ubiquitin ligase activity Cellular component cytoplasm cytosol anaphase-promoting complex nucleus nucleoplasm nucleolus cullin-RING ubiquitin ligase complex Biological process protein K11-linked ubiquitination cell division protein ubiquitination cell cycle anaphase-promoting complex-dependent catabolic process mitotic cell cycle positive regulation of mitotic metaphase/anaphase transition ubiquitin-dependent protein catabolic process regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51529 66156 Ensembl ENSG00000141552 ENSMUSG00000025135 UniProt Q9NYG5 Q9CPX9 RefSeq (mRNA) NM_016476 NM_001002244 NM_001002245 NM_001002246 NM_001002247 NM_001002248 NM_001002249 NM_001289414 NM_001289415 NM_001289416 NM_001289417 NM_001289418 NM_001289419 NM_001289420 NM_001038230 NM_025389 RefSeq (protein) NP_001002244 NP_001002245 NP_001002246 NP_001002247 NP_001002248 NP_001002249 NP_001276343 NP_001276344 NP_001276345 NP_001276346 NP_001276349 NP_057560 NP_001033319 NP_079665 Location (UCSC) Chr 17: 81.89 – 81.9 Mb Chr 11: 120.49 – 120.5 Mb PubMed search [3] [4]
Wikidata
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Interactions

ANAPC11 has been shown to interact with ANAPC2^[7][8] and CDC27.^[5][9]