ANP32E

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.^[5][6] The ANP32E gene is located on chromosome 1q22.^[5] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.^[7] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis^[8] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.^[9]

ANP32E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CAY, 4NFT
Identifiers
Aliases	ANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDs	OMIM: 609611; MGI: 1913721; HomoloGene: 137403; GeneCards: ANP32E; OMA:ANP32E - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,218,417 bp[1] End 150,236,156 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,836,558 bp[2] End 95,854,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone caput epididymis corpus epididymis dorsal motor nucleus of vagus nerve ventricular zone epithelium of nasopharynx retinal pigment epithelium tail of epididymis Epithelium of choroid plexus gingival epithelium Top expressed in tail of embryo neural layer of retina genital tubercle otic vesicle pineal gland otic placode cumulus cell saccule ventricular zone abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding phosphatase inhibitor activity Cellular component cytoplasm nucleus Swr1 complex cytoplasmic vesicle Biological process negative regulation of catalytic activity histone exchange nucleosome assembly nucleocytoplasmic transport regulation of apoptotic process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81611 66471 Ensembl ENSG00000143401 ENSMUSG00000015749 UniProt Q9BTT0 P97822 RefSeq (mRNA) NM_001136478 NM_001136479 NM_001280559 NM_001280560 NM_030920 NM_001253757 NM_001253758 NM_023210 RefSeq (protein) NP_001129950 NP_001129951 NP_001267488 NP_001267489 NP_112182 NP_001240686 NP_001240687 NP_075699 Location (UCSC) Chr 1: 150.22 – 150.24 Mb Chr 3: 95.84 – 95.85 Mb PubMed search [3] [4]
Wikidata
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See also

• ANP32A, ANP32B, ANP32C, ANP32D