AP1G1

AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.^[5][6]

AP1G1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IU1
Identifiers
Aliases	AP1G1, ADTG, CLAPG1, adaptor related protein complex 1 gamma 1 subunit, adaptor related protein complex 1 subunit gamma 1, USRISD
External IDs	OMIM: 603533; MGI: 101919; HomoloGene: 47995; GeneCards: AP1G1; OMA:AP1G1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.2 Start 71,729,000 bp[1] End 71,809,201 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 57.26 cM Start 110,505,186 bp[2] End 110,590,836 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon epithelium of colon sperm corpus epididymis islet of Langerhans sural nerve left testis middle temporal gyrus right testis Top expressed in genital tubercle tail of embryo cumulus cell granulocyte neural layer of retina dentate gyrus of hippocampal formation granule cell Paneth cell ventricular zone spermatocyte right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity GTP-dependent protein binding protein binding kinesin binding Cellular component recycling endosome clathrin-coated endocytic vesicle membrane Golgi apparatus trans-Golgi network membrane membrane intracellular membrane-bounded organelle Golgi membrane lysosomal membrane AP-type membrane coat adaptor complex clathrin-coated vesicle membrane membrane coat cytoplasmic vesicle membrane cytoplasmic vesicle clathrin-coated vesicle clathrin adaptor complex cytoplasm cytosol AP-1 adaptor complex Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitigation of host defenses by virus Golgi to lysosome transport positive regulation of natural killer cell degranulation melanosome organization endosome to melanosome transport protein transport intracellular protein transport positive regulation of natural killer cell mediated cytotoxicity vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 164 11765 Ensembl ENSG00000166747 ENSMUSG00000031731 UniProt O43747 P22892 RefSeq (mRNA) NM_001128 NM_001030007 NM_001301211 NM_009677 RefSeq (protein) NP_001025178 NP_001119 NP_001288140 NP_033807 Location (UCSC) Chr 16: 71.73 – 71.81 Mb Chr 8: 110.51 – 110.59 Mb PubMed search [3] [4]
Wikidata
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Function

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

AP1G1 has been shown to interact with:

• AP1B1,^[6][8][9]
• AP1GBP1,^[10][11]
• AP1M1,^[8][9]
• AP1S1,^[6][8][9]
• NECAP2,^[12]
• RABEP1,^[10][13] and
• Synaptophysin.^[14]