AP1M1

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.^[5][6]

AP1M1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W63, 4EMZ, 4EN2, 4HMY, 4P6Z
Identifiers
Aliases	AP1M1, AP47, CLAPM2, CLTNM, MU-1A, adaptor related protein complex 1 mu 1 subunit, adaptor related protein complex 1 subunit mu 1, mu1A
External IDs	OMIM: 603535; MGI: 102776; HomoloGene: 4017; GeneCards: AP1M1; OMA:AP1M1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 16,197,854 bp[1] End 16,245,906 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.92 cM Start 72,993,862 bp[2] End 73,011,229 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right lobe of liver left testis right testis stromal cell of endometrium prefrontal cortex mucosa of ileum monocyte ganglionic eminence right coronary artery Top expressed in seminiferous tubule internal carotid artery external carotid artery granulocyte facial motor nucleus endothelial cell of lymphatic vessel neural layer of retina Rostral migratory stream ganglionic eminence vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol clathrin-coated endocytic vesicle membrane Golgi apparatus trans-Golgi network membrane membrane Golgi membrane lysosomal membrane clathrin-coated vesicle membrane extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle clathrin adaptor complex plasma membrane specific granule membrane Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitigation of host defenses by virus melanosome organization endosome to melanosome transport protein transport intracellular protein transport vesicle-mediated transport viral process neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8907 11767 Ensembl ENSG00000072958 ENSMUSG00000003033 UniProt Q9BXS5 P35585 RefSeq (mRNA) NM_001130524 NM_032493 NM_007456 RefSeq (protein) NP_001123996 NP_115882 NP_031482 Location (UCSC) Chr 19: 16.2 – 16.25 Mb Chr 8: 72.99 – 73.01 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.^[7]

Interactions

AP1M1 has been shown to interact with VAMP4^[8] and AP1G1.^[9][10]