AP1M2

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.^[5][6]

AP1M2
Identifiers
Aliases	AP1M2, AP1-mu2, HSMU1B, MU-1B, MU1B, mu2, adaptor related protein complex 1 mu 2 subunit, adaptor related protein complex 1 subunit mu 2
External IDs	OMIM: 607309; MGI: 1336974; HomoloGene: 55906; GeneCards: AP1M2; OMA:AP1M2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,572,671 bp[1] End 10,587,315 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.76 cM Start 21,205,571 bp[2] End 21,223,633 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum olfactory zone of nasal mucosa right lobe of thyroid gland oocyte right uterine tube left lobe of thyroid gland islet of Langerhans body of pancreas human kidney Top expressed in pyloric antrum transitional epithelium of urinary bladder ileum epithelium of stomach upper respiratory tract olfactory system nasal epithelium olfactory epithelium submandibular gland lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol Golgi apparatus trans-Golgi network membrane intracellular membrane-bounded organelle membrane Golgi membrane lysosomal membrane clathrin-coated vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle clathrin adaptor complex Biological process protein targeting vesicle targeting antigen processing and presentation of exogenous peptide antigen via MHC class II mitigation of host defenses by virus protein transport intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10053 11768 Ensembl ENSG00000129354 ENSMUSG00000003309 UniProt Q9Y6Q5 Q9WVP1 RefSeq (mRNA) NM_001300887 NM_005498 NM_001110300 NM_009678 RefSeq (protein) NP_001287816 NP_005489 NP_001103770 NP_033808 Location (UCSC) Chr 19: 10.57 – 10.59 Mb Chr 9: 21.21 – 21.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.^[6]

Interactions

AP1M2 has been shown to interact with AP2B1.^[7]