AP2B1

AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.^[5][6][7]

AP2B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI
Identifiers
Aliases	AP2B1, ADTB2, AP105B, AP2-BETA, CLAPB1, adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1
External IDs	OMIM: 601025; MGI: 1919020; HomoloGene: 68176; GeneCards: AP2B1; OMA:AP2B1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,578,046 bp[1] End 35,726,413 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 83,189,850 bp[2] End 83,295,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Brodmann area 10 islet of Langerhans stromal cell of endometrium rectum right frontal lobe cingulate gyrus anterior cingulate cortex C1 segment Top expressed in spermatid seminiferous tubule spermatocyte dentate gyrus of hippocampal formation granule cell superior frontal gyrus lateral septal nucleus tail of embryo cerebellar cortex somite subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin adaptor activity protein-containing complex binding clathrin binding signal sequence binding protein binding cargo receptor activity Cellular component endocytic vesicle membrane cytosol clathrin-coated endocytic vesicle membrane membrane clathrin coat plasma membrane trans-Golgi network endolysosome membrane membrane coat clathrin-coated pit clathrin adaptor complex AP-2 adaptor complex clathrin-coated endocytic vesicle postsynapse glutamatergic synapse Biological process cardiac septum development endocytosis ventricular septum development antigen processing and presentation of exogenous peptide antigen via MHC class II ephrin receptor signaling pathway mitigation of host defenses by virus coronary vasculature development aorta development heart development clathrin-dependent endocytosis clathrin coat assembly protein transport intracellular protein transport vesicle-mediated transport microtubule-based movement Wnt signaling pathway, planar cell polarity pathway membrane organization neurotransmitter receptor internalization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance transport positive regulation of endocytosis postsynaptic neurotransmitter receptor internalization negative regulation of neuron death positive regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 163 71770 Ensembl ENSG00000006125 ENSMUSG00000035152 UniProt P63010 Q9DBG3 RefSeq (mRNA) NM_001030006 NM_001282 NM_001035854 NM_027915 RefSeq (protein) NP_001025177 NP_001273 NP_001030931 NP_082191 Location (UCSC) Chr 17: 35.58 – 35.73 Mb Chr 11: 83.19 – 83.3 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

AP2B1 has been shown to interact with:

• AP1M2,^[8]
• Arrestin beta 2,^[9][10]
• BUB1B,^[11]
• LDLRAP1^[8][12] and
• TGF beta receptor 2.^[13]