AP2A2

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.^[5][6][7]

AP2A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
Identifiers
Aliases	AP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
External IDs	OMIM: 607242; MGI: 101920; HomoloGene: 5335; GeneCards: AP2A2; OMA:AP2A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 924,881 bp[1] End 1,012,245 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,142,086 bp[2] End 141,212,924 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum spleen superior frontal gyrus sural nerve right frontal lobe subcutaneous adipose tissue prefrontal cortex canal of the cervix pituitary gland ganglionic eminence Top expressed in perirhinal cortex entorhinal cortex neural layer of retina dentate gyrus of hippocampal formation granule cell stroma of bone marrow CA3 field medullary collecting duct superior frontal gyrus primary visual cortex cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin adaptor activity protein binding protein kinase binding lipid binding protein domain specific binding disordered domain specific binding molecular function Cellular component endocytic vesicle membrane cytosol clathrin-coated endocytic vesicle membrane membrane plasma membrane endolysosome membrane membrane coat clathrin-coated pit AP-2 adaptor complex clathrin adaptor complex secretory granule membrane cytoplasmic vesicle ficolin-1-rich granule membrane clathrin-coated endocytic vesicle Biological process endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II ephrin receptor signaling pathway mitigation of host defenses by virus clathrin-dependent endocytosis protein transport intracellular protein transport vesicle-mediated transport microtubule-based movement Wnt signaling pathway, planar cell polarity pathway neutrophil degranulation membrane organization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 161 11772 Ensembl ENSG00000281385 ENSG00000280759 ENSG00000183020 ENSMUSG00000002957 UniProt O94973 P17427 RefSeq (mRNA) NM_001242837 NM_012305 NM_007459 NM_001357068 RefSeq (protein) NP_001229766 NP_036437 NP_031485 NP_001343997 Location (UCSC) Chr 11: 0.92 – 1.01 Mb Chr 7: 141.14 – 141.21 Mb PubMed search [3] [4]
Wikidata
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Interactions

AP2A2 has been shown to interact with EPN1^[8] and SHC1.^[9]