EPN1

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.^[5][6][7]

EPN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1INZ
Identifiers
Aliases	EPN1, epsin 1
External IDs	OMIM: 607262; MGI: 1333763; HomoloGene: 32172; GeneCards: EPN1; OMA:EPN1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,675,226 bp[1] End 55,709,858 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 5,080,235 bp[2] End 5,098,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart body of stomach mucosa of transverse colon right frontal lobe right auricle of heart anterior cingulate cortex left testis muscle of thigh right testis body of pancreas Top expressed in Ileal epithelium perirhinal cortex CA3 field entorhinal cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell lactiferous gland choroid plexus of fourth ventricle ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding lipid binding Cellular component cytoplasm plasma membrane clathrin-coated pit membrane nucleus cytosol Biological process Notch signaling pathway female pregnancy negative regulation of epidermal growth factor receptor signaling pathway in utero embryonic development endocytosis embryonic organ development membrane organization negative regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29924 13854 Ensembl ENSG00000063245 ENSMUSG00000035203 UniProt Q9Y6I3 Q80VP1 RefSeq (mRNA) NM_001130071 NM_001130072 NM_013333 NM_001321263 NM_001252454 NM_010147 RefSeq (protein) NP_001123543 NP_001123544 NP_001308192 NP_037465 NP_001239383 NP_034277 NP_001359429 Location (UCSC) Chr 19: 55.68 – 55.71 Mb Chr 7: 5.08 – 5.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM]^[7]

Interactions

EPN1 has been shown to interact with REPS2,^[6] AP2A2^[5] and EPS15.^[5]