AP2M1

AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.^[5]

AP2M1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H6E, 2JKT, 2JKR, 2VGL, 2BP5
Identifiers
Aliases	AP2M1, AP50, CLAPM1, mu2, adaptor related protein complex 2 mu 1 subunit, adaptor related protein complex 2 subunit mu 1, MRD60
External IDs	OMIM: 601024; MGI: 1298405; HomoloGene: 3000; GeneCards: AP2M1; OMA:AP2M1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,174,689 bp[1] End 184,184,214 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 20,354,228 bp[2] End 20,363,659 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex right hemisphere of cerebellum right adrenal gland right adrenal cortex stromal cell of endometrium left adrenal gland left adrenal cortex cingulate gyrus ganglionic eminence Top expressed in primary visual cortex Cortex of frontal lobe olfactory bulb superior frontal gyrus dentate gyrus of hippocampal formation granule cell neural layer of retina neural tube Mesencephalon hippocampus proper Hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding clathrin adaptor activity transporter activity transmembrane transporter binding protein binding signal sequence binding low-density lipoprotein particle receptor binding Cellular component extracellular exosome lysosomal membrane AP-2 adaptor complex endocytic vesicle membrane cytosol membrane endolysosome membrane clathrin adaptor complex clathrin-coated pit clathrin-coated endocytic vesicle membrane plasma membrane clathrin-coated endocytic vesicle Biological process ephrin receptor signaling pathway mitigation of host defenses by virus clathrin-dependent endocytosis negative regulation of protein localization to plasma membrane antigen processing and presentation of exogenous peptide antigen via MHC class II endocytosis protein transport vesicle-mediated transport intracellular protein transport Wnt signaling pathway, planar cell polarity pathway microtubule-based movement membrane organization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance transport vesicle budding from membrane receptor internalization regulation of vesicle size Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1173 11773 Ensembl ENSG00000161203 ENSMUSG00000022841 UniProt Q96CW1 P84091 RefSeq (mRNA) NM_004068 NM_001025205 NM_001311198 NM_009679 NM_001302970 RefSeq (protein) NP_001020376 NP_001298127 NP_004059 NP_001289899 NP_033809 Location (UCSC) Chr 3: 184.17 – 184.18 Mb Chr 16: 20.35 – 20.36 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

AP2M1 has been shown to interact with CTLA-4^[7][8] and Alpha-1B adrenergic receptor.^[9]