Top Qs
Timeline
Chat
Perspective
AP2M1
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Remove ads
AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.[5]
Remove ads
Function
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.[6]
Remove ads
Interactions
AP2M1 has been shown to interact with CTLA-4[7][8] and Alpha-1B adrenergic receptor.[9]
References
Further reading
External links
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads