Alpha-1B adrenergic receptor

The alpha-1B adrenergic receptor (α_1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.^[5] The crystal structure of the α_1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.^[6]

ADRA1B
Identifiers
Aliases	ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs	OMIM: 104220; MGI: 104774; HomoloGene: 55477; GeneCards: ADRA1B; OMA:ADRA1B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 159,865,080 bp[1] End 159,973,012 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.1|11 25.81 cM Start 43,665,433 bp[2] End 43,792,037 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver thoracic aorta ascending aorta Descending thoracic aorta popliteal artery tibial arteries prefrontal cortex cingulate gyrus anterior cingulate cortex right lung Top expressed in left lobe of liver superior frontal gyrus right ventricle primary visual cortex lateral geniculate nucleus dentate gyrus of hippocampal formation granule cell embryo medial dorsal nucleus nucleus of stria terminalis right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity adrenergic receptor activity protein heterodimerization activity alpha1-adrenergic receptor activity protein binding Cellular component integral component of membrane membrane integral component of plasma membrane nucleus nuclear membrane plasma membrane cytoplasm caveola Biological process regulation of muscle contraction intracellular signal transduction norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure glucose homeostasis adenylate cyclase-modulating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling multicellular organism development adenylate cyclase-activating adrenergic receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway regulation of vasoconstriction positive regulation of vasoconstriction regulation of cardiac muscle contraction cell population proliferation positive regulation of smooth muscle contraction positive regulation of MAPK cascade signal transduction G protein-coupled receptor signaling pathway neuron-glial cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147 11548 Ensembl ENSG00000170214 ENSMUSG00000050541 UniProt P35368 P97717 RefSeq (mRNA) NM_000679 NM_001284380 NM_001284381 NM_007416 RefSeq (protein) NP_000670 n/a Location (UCSC) Chr 5: 159.87 – 159.97 Mb Chr 11: 43.67 – 43.79 Mb PubMed search [3] [4]
Wikidata
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Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.^[5]

Ligands

Antagonists

• L-765,314^[7]
• Risperidone
• Brexpiprazole

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.^[8] A role in regulation of dopaminergic neurotransmission has also been suggested.^[9][10]

See also

• Adrenergic receptor