APBA2

Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.^[5][6]

APBA2
Identifiers
Aliases	APBA2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L, amyloid beta precursor protein binding family A member 2
External IDs	OMIM: 602712; MGI: 1261791; HomoloGene: 4021; GeneCards: APBA2; OMA:APBA2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q13.1 Start 28,884,483 bp[1] End 29,118,315 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 C|7 34.65 cM Start 64,501,706 bp[2] End 64,753,878 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus right hemisphere of cerebellum primary visual cortex prefrontal cortex right frontal lobe Brodmann area 9 anterior cingulate cortex hippocampus proper ganglionic eminence C1 segment Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus perirhinal cortex CA3 field entorhinal cortex cerebellar cortex hippocampus proper primary motor cortex cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amyloid-beta binding protein binding identical protein binding Cellular component plasma membrane synaptic vesicle Schaffer collateral - CA1 synapse cytoplasm dendritic spine synapse Biological process regulation of gene expression protein transport in utero embryonic development locomotory behavior nervous system development multicellular organism growth chemical synaptic transmission regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 321 11784 Ensembl ENSG00000034053 ENSG00000276495 ENSMUSG00000030519 UniProt Q99767 P98084 RefSeq (mRNA) NM_001130414 NM_005503 NM_001353788 NM_001353789 NM_001353790 NM_001353791 NM_001353792 NM_001353793 NM_001353794 NM_001353795 NM_001353796 NM_001353797 NM_001379685 NM_001291166 NM_001291167 NM_007461 RefSeq (protein) NP_001123886 NP_005494 NP_001340717 NP_001340718 NP_001340719 NP_001340720 NP_001340721 NP_001340722 NP_001340723 NP_001340724 NP_001340725 NP_001340726 NP_001366614 NP_001278095 NP_001278096 NP_031487 Location (UCSC) Chr 15: 28.88 – 29.12 Mb Chr 7: 64.5 – 64.75 Mb PubMed search [3] [4]
Wikidata
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Structure

This protein has phosphotyrosine-binding domain (PTB domain or PID) in the middle and two PDZ domains at C-terminal.

Function

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.^[6]

Interactions

APBA2 has been shown to interact with CLSTN1,^[7][8] RELA^[9] and amyloid precursor protein.^[7][10][11]