CLSTN1

Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.^[5][6]

CLSTN1
Identifiers
Aliases	CLSTN1, ALC-ALPHA, CDHR12, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CST-1, calsyntenin 1
External IDs	OMIM: 611321; MGI: 1929895; HomoloGene: 8814; GeneCards: CLSTN1; OMA:CLSTN1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 9,728,926 bp[1] End 9,823,984 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 149,670,925 bp[2] End 149,733,356 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole postcentral gyrus Brodmann area 10 paraflocculus of cerebellum middle temporal gyrus orbitofrontal cortex superior frontal gyrus Brodmann area 46 cerebellar vermis right hemisphere of cerebellum Top expressed in primary motor cortex cingulate gyrus neural layer of retina prefrontal cortex habenula primary visual cortex superior frontal gyrus medial dorsal nucleus piriform cortex medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function X11-like protein binding calcium ion binding amyloid-beta binding protein binding kinesin binding Cellular component integral component of membrane postsynaptic membrane Golgi apparatus cell projection endoplasmic reticulum membrane membrane Golgi membrane plasma membrane synapse extracellular region cell surface cell junction endoplasmic reticulum nucleus postsynaptic density postsynaptic endosome glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane integral component of spine apparatus membrane Biological process cell adhesion positive regulation of synaptic transmission regulation of cell growth homophilic cell adhesion via plasma membrane adhesion molecules positive regulation of synapse assembly regulation of synapse maturation neurotransmitter receptor transport to postsynaptic membrane vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22883 65945 Ensembl ENSG00000171603 ENSMUSG00000039953 UniProt O94985 Q9EPL2 RefSeq (mRNA) NM_014944 NM_001009566 NM_001302883 NM_001290989 NM_023051 RefSeq (protein) NP_001009566 NP_001289812 NP_055759 NP_001277918 NP_075538 Location (UCSC) Chr 1: 9.73 – 9.82 Mb Chr 4: 149.67 – 149.73 Mb PubMed search [3] [4]
Wikidata
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Clinical relevance

Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer's disease.^[7]

Interactions

CLSTN1 has been shown to interact with APBA2^[8][9] and Amyloid precursor protein.^[8][9]