APIP

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.^[5][6][7] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity^[8][9] which is involved in the methionine salvage pathway.

APIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6R
Identifiers
Aliases	APIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDs	OMIM: 612491; MGI: 1926788; HomoloGene: 6277; GeneCards: APIP; OMA:APIP - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 34,853,094 bp[1] End 34,916,379 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E2 Start 102,904,020 bp[2] End 102,922,989 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment muscle of thigh right adrenal gland corpus callosum right adrenal cortex monocyte skeletal muscle tissue left adrenal gland left adrenal cortex gastrocnemius muscle Top expressed in right ventricle interventricular septum zygote cardiac muscle tissue of left ventricle muscle of thigh secondary oocyte right kidney digastric muscle temporal muscle brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding lyase activity identical protein binding methylthioribulose 1-phosphate dehydratase activity zinc ion binding Cellular component cytoplasm cytosol Biological process methionine biosynthetic process negative regulation of apoptotic process cellular amino acid biosynthetic process regulation of ERK1 and ERK2 cascade apoptotic process pyroptosis protein homotetramerization L-methionine salvage from methylthioadenosine L-methionine salvage from S-adenosylmethionine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51074 56369 Ensembl ENSG00000149089 ENSMUSG00000010911 UniProt Q96GX9 Q9WVQ5 RefSeq (mRNA) NM_015957 NM_019735 NM_001355473 NM_001355474 RefSeq (protein) NP_057041 NP_062709 NP_001342402 NP_001342403 Location (UCSC) Chr 11: 34.85 – 34.92 Mb Chr 2: 102.9 – 102.92 Mb PubMed search [3] [4]
Wikidata
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APIP deficiency is associated with cell death^[10] and cancer.

Interactions

APIP has been shown to interact with APAF1.^[6]