APOBEC3B

Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene.^[5][6][7]

APOBEC3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CQD, 5CQH, 5CQI, 5CQK, 2NBQ
Identifiers
Aliases	APOBEC3B, A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2, apolipoprotein B mRNA editing enzyme catalytic subunit 3B
External IDs	OMIM: 607110; MGI: 1933111; HomoloGene: 105420; GeneCards: APOBEC3B; OMA:APOBEC3B - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,982,347 bp[1] End 38,992,804 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.85 cM Start 79,775,860 bp[2] End 79,800,107 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad mucosa of transverse colon bone marrow rectum blood bone marrow cells islet of Langerhans stromal cell of endometrium duodenum appendix Top expressed in mesenteric lymph nodes thymus granulocyte bone marrow embryo aortic valve spleen subcutaneous adipose tissue epithelium of urethra ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines zinc ion binding catalytic activity hydrolase activity metal ion binding deoxycytidine deaminase activity RNA binding cytidine deaminase activity Cellular component nucleus cytoplasm Biological process negative regulation of transposition innate immune response immune system process defense response to virus cytidine deamination cytidine to uridine editing DNA demethylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9582 80287 Ensembl ENSG00000179750 ENSMUSG00000009585 UniProt Q9UH17 Q99J72 RefSeq (mRNA) NM_004900 NM_001270411 NM_001160415 NM_030255 NM_001347041 RefSeq (protein) NP_001257340 NP_004891 NP_001153887 NP_001333970 NP_084531 Location (UCSC) Chr 22: 38.98 – 38.99 Mb Chr 15: 79.78 – 79.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and APOBEC3B proteins can cause specific mutations in cancer genomes called APOBEC mutagenesis and several factors including genetic and environmental influence this mutation pattern among patients specifically in bladder and breast cancer.^[7] This gene is also overexpressed in multiple myeloma, possibly aiding its formation.^[8]